The Spireites hit Barnet for six at the Technique Stadium in a game that saw Akwasi Asante take home the match ball with his outstanding hat-trick.
Will Evans was suspended after picking up his fifth yellow card against Sutton United in midweek; Josef Yarney took the skipper’s place. Curtis Weston was given the captain’s armband.
James Rowe made a second change to the side with Scott Boden replacing top scorer Tom Denton.
Chesterfield really should have had their noses in front within the first five minutes. Joel Taylor whipped in a wonderful cross from the left, but Boden couldn’t find the right connection and nodded his header wide.
Weston sent Tom Whelan through on goal in the 12th minute with just Scott Loach to beat, but former Spireite Jerome Binnom-Williams made a last-ditch challenge to deny the midfielder.
The closest the away side came to scoring was through Mahammadu Faal. A mix-up between Haydn Hollis and Laurence Maguire allowed the Barnet player to fire an effort towards goal which rolled wide of the post.
Asante should have fired Chesterfield into the lead just after the half-hour mark. George Carline’s threaded through ball found the striker, but Asante failed to hit the target from close-range.
The Spireites finally took the lead with about five minutes of the first half remaining. Jak McCourt battled hard in midfield before sending Asante through on goal and he made no mistake, slotting the ball past Loach to send his team into the break with the lead.
A couple of minutes into the second half, the hosts almost doubled their lead. A lovely ball from McCourt found the head of Boden, who headed agonisingly wide of the goal.
Chesterfield were pushing hard to pull away from Barnet and saw Carline have an effort saved by Loach and Taylor volley wide.
The second goal finally came ten minutes into the second period; McCourt played a 50-yard ball that found Taylor in the box and he cut it back to Boden who hammered the ball home from close-range.
Two became three just minutes later. A McCourt corner eventually fell to Hollis and the defender tapped home from point-blank range to score his second goal in a week.
A fourth goal arrived with 15 minutes to go. Asante received a ball in the area from Whelan, switched it on to his right foot and fired past the Barnet goalkeeper.
Unbelievably Asante wrapped up his hat-trick in fashionable style. The forward latched onto the ball out on the left, was pushed off the pitch and controlled the ball on the byline all before making his way into the box and effortlessly striking home for his first three-goal haul for the Spireites.
Kyle Letheren made a fine save five minutes from time to keep out an effort from Parrett and protect the clean sheet.
The Spireites had time for a sixth, which came on the cusp of the 90th minute. Liam Mandeville wrong-footed the defender before chipping the ball across to McCourt and the midfielder bundled home for a deserved goal.
Chesterfield: Letheren, Carline (Cropper 64), Yarney, Hollis, Maguire, Taylor, McCourt, Weston, Whelan, Boden (Tom Denton 60), Asante (Mandeville 80).
Unused Substitutes: Tyler Denton, Smith.